Browsing Experimentally Confirmed database

Result: Your query found 9 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
cadC
  • BacMet ID: BAC0056
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258 (Staphylococcus aureus)
  • Compound: Cadmium (Cd), Bismuth (Bi), Zinc (Zn), Lead (Pb)
  • Description: Found in cad operon; bind to cad operator/promoter, its a repressor protein in the operon; Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Binds 2 metal ions per subunit. Metal binding to the N-terminal regulatory site causes the repressor to dissociate from the DNA
  • Length (amino acid): 122
  • Reference: Endo et al. 1995; Pubmed- 7543476

    		• Similar resistance genes in 'BacMet Predicted database'
    nmtR
  • BacMet ID: BAC0281
  • Code for: Regulator
  • Family: ArsR-SmtB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Nickel (Ni), Cadmium (Cd), Lead (Pb)
  • Description: Represses transcription of ctpJ/nmtA, by binding to its promoter region
  • Length (amino acid): 120
  • Reference: Cavet et al. 2002; Pubmed- 12163508

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrA
  • BacMet ID: BAC0298
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839), Plasmid pLVPK (Klebsiella pneumoniae)
  • Compound: Lead (Pb)
  • Description: pbrA, a P-type ATPase (involved in efflux); involved in Pb(II) resistance; part of the lead resistance determinant pbr operon (pbrABCD) which combines functions involved in uptake, efflux, and accumulation of Pb(II)
  • Length (amino acid): 799
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrB/pbrC
  • BacMet ID: BAC0299
  • Code for: Enzyme
  • Family: Peptidase A8 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)), Plasmid pLVPK (Klebsiella pneumoniae)
  • Compound: Lead (Pb)
  • Description: Lipoprotein signal peptidase 3 (pbrB); a predicted integral membrane protein and a putative signal peptidase (involved in efflux); part of the lead resistance determinant pbr operon (pbrABCD) which combines functions involved in uptake, efflux, and accumulation of Pb(II)
  • Length (amino acid): 358
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrD
  • BacMet ID: BAC0300
  • Code for: Binding protein
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Lead (Pb)
  • Description: PbrD, Pb(II) binding protein involved in Pb(II) resistance; a intracellular Pb binding protein (involved in Pb++ accumulation); function as a chaperone for Pb(II) or involved in Pb(II) sequestration ; PbrD is not absolutely required for Pb(II) resistance, but cells lacking PbrD show a decreased accumulation of Pb(II); part of the lead resistance determinant pbr operon (pbrABCD) which combines functions involved in uptake, efflux, and accumulation of Pb(II)
  • Length (amino acid): 289
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrR
  • BacMet ID: BAC0301
  • Code for: Regulator
  • Family: MerR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Herbaspirillum seropedicae (strain SmR1)
  • Location: Plasmid pLVPK (Klebsiella pneumoniae), Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839))
  • Compound: Lead (Pb)
  • Description: A transcription factor, pbrR belonging to the merR family
  • Length (amino acid): 150
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrT
  • BacMet ID: BAC0302
  • Code for: Membrane Transporter
  • Family: Contains 1 cytochrome C domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxydans xylosoxydans
  • Location: Plasmid pA81
  • Compound: Lead (Pb)
  • Description: A lead (Pb++) uptake protein PbrT
  • Length (amino acid): 630
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    zntA/yhhO
  • BacMet ID: BAC0461
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Lead (Pb), Cadmium (Cd), Zinc (Zn)
  • Description: Lead, cadmium, zinc and mercury-transporting ATPase ZntA; Involved in export of lead, cadmium, zinc and mercury; located in inner cell membrane.
  • Length (amino acid): 732
  • Reference: Rensing et al. 1997; Pubmed- 9405611, Beard et al. 1997; Pubmed- 9364914

    		• Similar resistance genes in 'BacMet Predicted database'
    zraS/hydG
  • BacMet ID: BAC0468
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Lead (Pb)
  • Description: Sensor protein ZraS; Member of the two-component regulatory system ZraS/ZraR. Functions as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium.
  • Length (amino acid): 465
  • Reference: Leonshartsberger et al. 2001; Pubmed- 11243806

    		• Similar resistance genes in 'BacMet Predicted database'
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